[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 2 (September- 2020) ::
Caspian J Dent Res 2020, 9(2): 26-34 Back to browse issues page
CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction
Azadeh Majidian , Maryam Seyedmajidi , Hamid Abbaszadeh , Majid Sharbatdaran , Sina Jafari , Hemmat Gholinia
,Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, IR Iran . , hamidabbaszadeh@yahoo.com
Abstract:   (1104 Views)
Introduction: Oral lichen planus (OLP) is an immunologically mediated mucocutaneous diseases. Langerhans cells (LCs) are antigen presenting cells resident within oral mucosa which, together with intraepithelial lymphocytes, play a role in mucosal defense. The aim of present study was to determine the immunohistochemical expression of LC in oral lichenoid reaction  (OLR) and OLP compared with normal oral mucosa (NOM).
Materials & Methods: In this cross-sectional study, 61 oral mucosal specimens diagnosed histopathologically as OLP (n=31) and OLR (n=30) and 11 NOM were used to study the immunohistochemical expression of CD1a. The CD1a positive LCs in three regions (basal, suprabasal, and connective tissue) were counted in six randomly selected fields. Data were analyzed using the SPSS 24, T-test, ANOVA, LSD, Games-Howell tests. P<.05 was considered significant.
Results: CD1a expression in OLP and OLR was significantly higher compared to NOM (P<0.001). CD1a expression in OLP was also significantly higher than OLR (P=0.009). There was a statistically significant difference between the three groups in basal, suprabasal and connective tissue regions (P<0.001).  The mean of CD1a positive cells in the basal, suprabasal and connective tissue regions was significantly higher in the OLP group than OLR and NOM. Also, in comparison between OLR and NOM, the OLR group had significantly more CD1a positive cells (P<0.05).
Conclusion: Increasing the number of CD1a in OLP and OLR compared with the NOM indicates the role of LC in the pathogenesis of these diseases.
Keywords: Lichen planus, Lichenoid eruption, Langerhans cells, Immunohistochemistry
Full-Text [PDF 1513 kb]   (276 Downloads)    
Type of Study: Original Article | Subject: Oral & Maxillofacial Pathology
Send email to the article author

Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Majidian A, Seyedmajidi M, Abbaszadeh H, Sharbatdaran M, Jafari S, Gholinia H. CD-1a immunoexpression in oral lichen planus and oral lichenoid reaction. Caspian J Dent Res. 2020; 9 (2) :26-34
URL: http://cjdr.ir/article-1-285-en.html

Volume 9, Issue 2 (September- 2020) Back to browse issues page
مجله تحقیقات دندانپزشکی کاسپین Caspian Journal of Dental Research
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4256