Volume 11, Issue 2 (September- 2022)
Caspian J Dent Res 2022, 11(2): 85-90 |
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Yadollahzade A, Amiriani T, Fakhari E. Effects of full-mouth disinfection on the recurrence of helicobacter pylori infection. Caspian J Dent Res 2022; 11 (2) :85-90
URL: http://cjdr.ir/article-1-371-en.html
URL: http://cjdr.ir/article-1-371-en.html
,Dental Research Center, Golestan University of Medical Sciences, Gorgan, Iran. , fakhari_85@yahoo.com
Abstract: (1895 Views)
Introduction: The oral cavity has been suggested as a potential reservoir for Helicobacter pylori (H. pylori), which could be a major cause of reinfection after standard systemic therapy. The aim of this study was to evaluate the effect of full-mouth disinfection (FMD) on the recurrence of H. pylori infection.
Materials & Methods: This randomized clinical trial was conducted on 40 patients with chronic periodontitis and H. pylori infection. Of these, 20 patients received quadruple anti-H. pylori therapy only (group A) and the other 20 patients received quadruple therapy plus FMD (group B). The presence of H. pylori was detected by a 14C-urea breath test (UBT) after 1 and 6 months. Data were analyzed with SPSS 16 using the chi-square test. A value of p<0.05 was considered statistically significant.
Results: Of 40 dyspeptic patients, 15(75%) and 18(90%) of 20 in groups A and B, respectively, had a negative UBT after 4 weeks. Of the patients with successful eradication of H. pylori after 1 month, 8(53.3%) and 6(33.3%) of 15 in group A and 18 in group B, respectively had a positive UBT after 6 months. There were no statistically significant differences between the two groups in the follow-up periods (p>0.05).
Conclusion: Implementation of quadruple therapy plus FMD may reduce recurrence of the infection although further studies are recommended to confirm the results.
Materials & Methods: This randomized clinical trial was conducted on 40 patients with chronic periodontitis and H. pylori infection. Of these, 20 patients received quadruple anti-H. pylori therapy only (group A) and the other 20 patients received quadruple therapy plus FMD (group B). The presence of H. pylori was detected by a 14C-urea breath test (UBT) after 1 and 6 months. Data were analyzed with SPSS 16 using the chi-square test. A value of p<0.05 was considered statistically significant.
Results: Of 40 dyspeptic patients, 15(75%) and 18(90%) of 20 in groups A and B, respectively, had a negative UBT after 4 weeks. Of the patients with successful eradication of H. pylori after 1 month, 8(53.3%) and 6(33.3%) of 15 in group A and 18 in group B, respectively had a positive UBT after 6 months. There were no statistically significant differences between the two groups in the follow-up periods (p>0.05).
Conclusion: Implementation of quadruple therapy plus FMD may reduce recurrence of the infection although further studies are recommended to confirm the results.
Type of Study: Research Paper |
Subject:
Periodontics
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