Volume 15, Issue 1 (March 2026)
Caspian J Dent Res 2026, 15(1): 38-45 |
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Ethics code: IR.MUBABOL.REC.1399.315
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Mahmoudzadeh S, Arash V, PourAmir M, Sheykhzade S. Salivary Cortisol Levels across Cervical Vertebral Maturation Stages in Girls Aged 8–18 Years. Caspian J Dent Res 2026; 15 (1) :38-45
URL: http://cjdr.ir/article-1-501-en.html
URL: http://cjdr.ir/article-1-501-en.html
Professor, Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran. , valiarash1859@gmail.com
Abstract: (20 Views)
Introduction: Accurate assessment of skeletal maturation is important for determining the timing of growth-modification orthodontic treatment. Cervical vertebral maturation (CVM) assessed by lateral cephalography is commonly used to estimate skeletal maturity, but it requires radiographic imaging. We investigated whether salivary cortisol concentrations vary across CVM stages and whether salivary cortisol could serve as a non-invasive complementary marker of skeletal maturation in adolescent girls.
Materials & Methods: In this observational study, 60 female patients aged 8–18 years who presented for orthodontic assessment were enrolled. Lateral cephalograms were used to classify participants according to CVM stage into four groups (CS1–CS2, CS3, CS4, and CS5–CS6). Unstimulated morning saliva samples were collected, and salivary cortisol concentrations were measured using an electrochemiluminescence assay. Statistical analysis included one-way ANOVA with post-hoc testing and independent samples t-tests. P<0.05 was considered statistically significant.
Results: Salivary cortisol concentrations increased progressively across CVM stages (p<0.001), with the highest concentrations observed in participants classified as CS5–CS6. Post-hoc comparisons showed significant differences between CS1–CS2 and the later maturation stages, as well as between CS3 and CS5–CS6. Salivary cortisol concentrations were also higher in post-menarcheal than in pre-menarcheal participants (p<0.001).
Conclusion: Given the strong correlation between salivary cortisol levels and CVM stages, salivary cortisol may serve as a non-invasive marker for assessing skeletal maturity in adolescent patients, particularly when cephalometric evaluation is not a priority.
Materials & Methods: In this observational study, 60 female patients aged 8–18 years who presented for orthodontic assessment were enrolled. Lateral cephalograms were used to classify participants according to CVM stage into four groups (CS1–CS2, CS3, CS4, and CS5–CS6). Unstimulated morning saliva samples were collected, and salivary cortisol concentrations were measured using an electrochemiluminescence assay. Statistical analysis included one-way ANOVA with post-hoc testing and independent samples t-tests. P<0.05 was considered statistically significant.
Results: Salivary cortisol concentrations increased progressively across CVM stages (p<0.001), with the highest concentrations observed in participants classified as CS5–CS6. Post-hoc comparisons showed significant differences between CS1–CS2 and the later maturation stages, as well as between CS3 and CS5–CS6. Salivary cortisol concentrations were also higher in post-menarcheal than in pre-menarcheal participants (p<0.001).
Conclusion: Given the strong correlation between salivary cortisol levels and CVM stages, salivary cortisol may serve as a non-invasive marker for assessing skeletal maturity in adolescent patients, particularly when cephalometric evaluation is not a priority.
Type of Study: Research Paper |
Subject:
Orthodontics
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