Volume 14, Issue 1 (March- 2025)
Caspian J Dent Res 2025, 14(1): 1-11 |
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Ethics code: IR.MUBABOL.HRI.REC.1403.080
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Talebi M, Haghanifar S, Kazemi S, Seyedmajidi S, Shalalvand M, Janabian N. Clinical and Radiographic Evaluation of the Efficacy of Chitosan-Containing Gel in the Treatment of periodontal intra bony Defects. Caspian J Dent Res 2025; 14 (1) :1-11
URL: http://cjdr.ir/article-1-486-en.html
URL: http://cjdr.ir/article-1-486-en.html
Mariyeh Talebi 
, Sina Haghanifar 
, Sohrab Kazemi , Seyedali Seyedmajidi , Mohsen Shalalvand , Niloofar Janabian *
, Sina Haghanifar , Sohrab Kazemi , Seyedali Seyedmajidi , Mohsen Shalalvand , Niloofar Janabian *
*Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Iran , niloofarjenabian@yahoo.com
Abstract: (43 Views)
Background: Intrabony defects are a key indicator of periodontal disease progression, and complete tissue regeneration is the primary goal of periodontal treatments. The aim of this study was to assess the clinical and radiographic efficacy of chitosan-containing gel in treating periodontal intrabony defects.
Methods: This double-blind randomized clinical trial was conducted on 26 proximal sites with combined three-walled or two-walled intrabony defects in maxillary and mandibular molars of adult patients, referred to the periodontology patients were randomly divided into two groups. The first group received a chitosan-containing gel, while the control group received a chitosan-free gel during surgery. Clinical parameters -Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), Gingival Recession (GR), and Gingival Index (GI) - were measured before and six months after surgery. Radiographic images were also analyzed before and after surgery using digital subtraction.
Results: In the group that receiving chitosan gel, there was a significantly greater reduction in PPD and CAL indices six months after surgery (P=0.001). The radiographic findings showed a statistically significant reduction in PPD and a significant improvement in CAL in the group receiving chitosan gel (P<0.001).
Conclusion: Based on the results, it is recommended to use chitosan gel as a supplementary material in bone defect surgeries.
Methods: This double-blind randomized clinical trial was conducted on 26 proximal sites with combined three-walled or two-walled intrabony defects in maxillary and mandibular molars of adult patients, referred to the periodontology patients were randomly divided into two groups. The first group received a chitosan-containing gel, while the control group received a chitosan-free gel during surgery. Clinical parameters -Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), Gingival Recession (GR), and Gingival Index (GI) - were measured before and six months after surgery. Radiographic images were also analyzed before and after surgery using digital subtraction.
Results: In the group that receiving chitosan gel, there was a significantly greater reduction in PPD and CAL indices six months after surgery (P=0.001). The radiographic findings showed a statistically significant reduction in PPD and a significant improvement in CAL in the group receiving chitosan gel (P<0.001).
Conclusion: Based on the results, it is recommended to use chitosan gel as a supplementary material in bone defect surgeries.
Keywords: Bone regeneration, Guided tissue regeneration, periodontal diseases, Chitosan, Periodontal attachment loss, periodontal pocket
Type of Study: Research Paper |
Subject:
Periodontics
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