Volume 13, Issue 1 (March- 2024)
Caspian J Dent Res 2024, 13(1): 36-42 |
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Nosratzehi S, Nosratzehi M, Alijani E, Payandeh A, Nosratzehi T, Shokri M. Salivary Glutathione Peroxidase Level in Patients with Hashimoto's Thyroiditis. Caspian J Dent Res 2024; 13 (1) :36-42
URL: http://cjdr.ir/article-1-435-en.html
URL: http://cjdr.ir/article-1-435-en.html
Shahin Nosratzehi 
, Mahin Nosratzehi , Ebrahim Alijani , Abolfazl Payandeh , Tahereh Nosratzehi * , Mostafa Shokri
, Mahin Nosratzehi , Ebrahim Alijani , Abolfazl Payandeh , Tahereh Nosratzehi * , Mostafa Shokri
Department of Oral Medicine, Oral and Dental Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. , taherehnosratzahi@yahoo.com
Abstract: (232 Views)
Introduction: The role of oxidative stress in pathogenesis and autoimmune diseases is well known. According to the function of the enzyme glutathione peroxidase via its antioxidant role in the body, this study was conducted to investigate the level of salivary glutathione peroxidase in patients with Hashimoto's thyroiditis compared to a control group.
Materials & Methods: In this case-control study, 30 patients with Hashimoto's thyroiditis and 30 healthy subjects were studied as a control group. The two studied groups were the same in terms of age (P=0.29) and sex (P=0.39). Five ml of total unstimulated saliva of the subjects was collected under resting conditions in a quiet room between 10 am and 12 noon (spitting method). The amount of glutathione peroxidase in the saliva samples of these subjects was measured using the ELISA method. The results were analyzed using Mann-Whitney and Chi-square statistical tests at a significance level of 0.05.
Results: The results showed that the mean age of the participants was 36.96±8.85 years. 71.7% of the participants were women with a mean age of 37.74±8.29 years and 28.3% were men with a mean age of 35±9.24 years. The level of salivary glutathione peroxidase was significantly lower in patients with Hashimoto's thyroiditis (13.26±13.55) than in the control group (24.95±18.06, P<0.002).
Conclusion: The level of salivary glutathione peroxidase in patients with Hashimoto's thyroiditis was significantly reduced than normal. Foods rich in antioxidants, especially glutathione, are recommended.
Materials & Methods: In this case-control study, 30 patients with Hashimoto's thyroiditis and 30 healthy subjects were studied as a control group. The two studied groups were the same in terms of age (P=0.29) and sex (P=0.39). Five ml of total unstimulated saliva of the subjects was collected under resting conditions in a quiet room between 10 am and 12 noon (spitting method). The amount of glutathione peroxidase in the saliva samples of these subjects was measured using the ELISA method. The results were analyzed using Mann-Whitney and Chi-square statistical tests at a significance level of 0.05.
Results: The results showed that the mean age of the participants was 36.96±8.85 years. 71.7% of the participants were women with a mean age of 37.74±8.29 years and 28.3% were men with a mean age of 35±9.24 years. The level of salivary glutathione peroxidase was significantly lower in patients with Hashimoto's thyroiditis (13.26±13.55) than in the control group (24.95±18.06, P<0.002).
Conclusion: The level of salivary glutathione peroxidase in patients with Hashimoto's thyroiditis was significantly reduced than normal. Foods rich in antioxidants, especially glutathione, are recommended.
Type of Study: Research Paper |
Subject:
Oral Medicine
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