Full mouth rehabilitation with fixed implant supported prostheses is one of the challenging treatments, because important factors in aesthetic and function should be considered. Implants' alignments and locations should be planned before the insertion unless the improper inclination and location of implants would lead to difficulties in patient's comfort, oral hygiene problem and inability to reconstruct the acceptable functional and aesthetical prosthesis.
This clinical report described the step by step prosthetic treatment procedure of full mouth rehabilitation and 1-year follow-up of a patient who underwent 10 and 8 implants in upper and lower jaw respectively, which were unaligned and malpositioned. In the cases of improper alignment and position of implants, modified prosthetic design with consideration of biomechanical principles should be incorporated to overcome the limitations.